The company claims that each dose provides a dog with a maximum of 12 weeks of protection against external parasites. Bravecto kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations [Ixodes scapularis (black-legged tick), Dermacentor variabilis (American dog tick), and Rhipicephalus sanguineus (brown dog tick)] for 12 weeks in dogs and puppies 6 months of age and older, and weighing 4.4 pounds or greater. Reviews: 1. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Walther FM, Allan MJ, Roepke RKA, Nuernberger MC. Beck S, Schein E, Baldermann C, von Samson-Himmelstjerna G, Kohn B. Made in Japan. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. For topical use only. The dogs in the control group (0X) were administered saline orally. The Bravecto topical solution for dogs and cats is included in the report mentioned in this story. Compend Contin Educ Pract Vet. Methods: The study was performed in privately-owned dogs naturally infested with S. scabiei var. Use caution in dogs with a history of seizures or neurologic disorders. For technical assistance or to report a suspected adverse drug reaction, contact Merck Animal Health at 1-800-224-5318. The speed of kill of fluralaner (Bravecto™) against lxodes ricinus ticks on dogs. 21. BRAVECTO Topical Solution for Cats: The most commonly reported adverse reactions include vomiting, itching, diarrhea, hair loss, decreased appetite, lethargy, and scabs/ulcerated lesions. BRAVECTO (Fluralaner Topical Solution) is available in five strengths for use in dogs (112.5 mg, 250 mg, 500 mg, 1000 mg, and 1400 mg fluralaner per tube). This includes the Brown Dog Tick, Lone Star Tick, American Dog … Parasites & Vectors. The fluoxetine was discontinued and the dog experienced no additional seizures during the study. Kidd L, Breitschwerdt EB. Bravecto is not effective against lone star ticks beyond 8 weeks of dosing. In a well-controlled field study BRAVECTO was used concurrently with other medications, such as vaccines, anthelmintics, antibiotics, steroids and sedatives. A fast-acting flea and tick protection in an easy-to-administer topical solution for dogs. Bravecto Topical Solution for Cats: The most common adverse reactions recorded in clinical trials were vomiting, itching, diarrhea, hair loss, decreased appetite, lethargy, and scabs/ulcerated lesions. This may be attributable to variability in the topical absorption rate between individual dogs. BRAVECTO should be administered topically as a single dose every 12 weeks according to the Dosage Schedule below to provide a minimum dose of 25 mg/kg body weight. Transmission times and prevention of tick-borne diseases in dogs. Parasites & Vectors. Bravecto Chew: The most common adverse reactions recorded in clinical trials were vomiting, decreased appetite, diarrhea, lethargy, polydipsia, and flatulence. should be administered the appropriate combination of tubes. Bravecto Topical Solution for Dogs kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations [Ixodes scapularis (black-legged tick), Dermacentor variabilis (American dog tick), and Rhipicephalus sanguineus (brown dog tick)] for 12 weeks in dogs and puppies 6 months of age and older, and weighing 4.4 pounds or greater. In a European field study conducted in 474 cats receiving topical fluralaner, there were three reports of facial dermatitis in humans after close contact with the application site within 4 days of application. Put on gloves provided at the point of sale. One dog had two seizures a day apart about 18 days after its first dose. 2003;(25)10:742-751.7. With Bravecto® Chew and Bravecto® Topical Solution for Dogs, dogs get 12 weeks* of flea and tick protection with a single treatment.1,2 That's nearly 3x longer than monthly treatments. The safety of Bravecto has not been established in breeding, pregnant or lactating cats. It takes up to 48 hours for the application site to become dry, but it will be noticeable for longer. If accidental skin contact occurs, wash the skin thoroughly with soap and water immediately. CAPCvet.org. Bravecto is an anti-tick and flea product that is available as chewable tablets and a topical solution. Quickview. 1. Bravecto Topical Solution for Cats [prescribing information]. Tick infestation and tick prophylaxis in dogs in the area of Berlin/Brandenburg – results of a questionnaire study. Background: The efficacy of fluralaner, formulated as a chewable tablet (Bravecto™) or topical solution (Bravecto™ Spot-on Solution), was evaluated against naturally acquired Sarcoptes scabiei var. For topical use only. In one study conducted with Ixodes scapularis and in one study conducted with Dermacentor variabilis, the onset of immediate efficacy (≥ 90% by Day 2) was reached later than Day 2. No known contraindications for Bravecto Chew for Dogs and Bravecto Topical Solution for Dogs and Cats.1-3No problems reported in field trials in dogs and cats that received Bravecto concurrently with other commonly used medication.1-3Bravecto has not been shown to be effective for 12 weeks1 duration in puppies or kittens less than 6 months of age. Use caution in dogs with a history of seizures. Bravecto (fluralaner) is also indicated for the treatment and control of Amblyomma americanum (lone star tick) infestations for 8 weeks in dogs and puppies 6 months of age and older, and weighing 4.4 pounds or greater. Starts at $39.85. 2014;7:83. Bravecto efficacy was evaluated in a 12-week in a clinical field study. It treats and prevents of flea infestations (Ctenocephalides felis) and also treats and controls several types of tick infestations for 12 weeks. The tube is open and ready for application when a breaking of the seal is felt. †Dogs over 123.0 lb. Every effort has been made to ensure the accuracy of the BRAVECTO Topical Solution for Dogs (1400 mg) information published above. Bravecto (Fluralaner) is a Topical Solution for Dogs that kills fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations [Ixodes scapularis (black-legged tick), Dermacentor variabilis (American dog tick), and Rhipicephalus sanguineus (brown dog tick)] for 12 weeks. Insect Biochem Mol Biol. This product was administered orally to intact, reproductively-sound male and female Beagles at a dose of up to 168 mg/kg (equivalent to 3X the maximum treatment dose) on three to four occasions at 8-week intervals. It is for the treatment and prevention of flea and tick infestations, for the treatment of demodicosis caused by Demodex canis and for the treatment of sarcoptic mange (Sarcoptes scabiei var. Gassel M, Wolf C, Noack S, Williams H, Ilg T. The novel isoxazoline ectoparasiticide fluralaner: selective inhibition of arthropod γ-aminobutyric acid- and L-glutamate-gated chloride channels and insecticidal/acaricidal activity. BRAVECTO, fluralaner, an ectoparasiticide belonging to the isoxazoline group, is systemically active against fleas and ticks. Fluralaner has a systemic mode of action and belongs to the class of isoxazoline-substituted benzamide derivatives. This site is intended for veterinary professionals. Each tube is packaged individually in a pouch. Now, after the launch of bravecto spot-on, there are different opinions about the efficacy of bravecto chewable or spot-on because one is oral and the other is a topical form of treatment. Bravecto Topical Solution for Dogs 88 - 123 LBS (2 Dose) List Price: $109.00 Parasites & Vectors. Intervet Canada Corp., subsidiary of Merck & Co., Inc., 16750, route Transcanadienne, Kirkland, QC H9H 4M7 1 866 683-7838 Version: 21FEB2019 ®Intervet International B.V. Used under license. BRAVECTO (Fluralaner Topical Solution) contains 280 mg/mL (28%) of fluralaner. Avoid contact with skin. Starts at $56.99. Use caution in cats with a history of neurologic abnormalities. ... Starts at $52.52. Berl Munch Tierarztl Wochenschr. Bravecto spot-on solution for dogs is a product for topical application containing fluralaner. Reviews: 259. Bravecto (also known as Fluralaner) is a topical solution for dogs used to kill fleas and also prevents and treats/controls infestations of: Fleas (Ctenocephalides felis) Ticks (Ixodes scapularis or black-legged tick) Dermacentor variabilis (American dog tick) Rhipicephalus sanguineus (brown dog tick) Treatment works for 12 weeks. BRAVECTO Chew: The most commonly reported adverse reactions include vomiting, decreased appetite, diarrhea, lethargy, polydipsia, and flatulence. Bravecto Topical Solution for Dogs is approved for pregnant, breeding, and lactating dogs.2 Bravecto (fluralaner) is also approved for use in dogs 6 months of age or older who weigh at least 4.4 pounds.2. 11. In this field study, the reported serious adverse reactions were not associated with the treatments. One treated animal experienced vomiting eight hours after administration. A second dog had a seizure 76 days after its first dose and 3 days after starting fluoxetine for separation anxiety. Bravecto (Fluralaner) is a Topical Solution for Dogs that kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations [Ixodes scapularis (black-legged tick), Dermacentor variabilis (American dog tick), and Rhipicephalus sanguineus (brown dog tick)] for 12 weeks. 2. This class has been associated with neurological adverse reactions including tremors, ataxia, and seizures. Dogs over 123.0 lb should be administered the appropriate combination of chew or tubes. Dogs with signs of flea allergy dermatitis showed improvement in erythema, alopecia, papules, scales, crusts, and excoriation as a direct result of eliminating flea infestations. There were no clinically-relevant, treatment-related effects on physical examination, body weights, food consumption, clinical pathology (hematology, clinical chemistries, coagulation tests, and urinalysis), gross pathology, histopathology, or organ weights. Peak fluralaner concentrations are achieved between 7 and 42 days following topical administration and the elimination half-life ranges between 14 and 29 days. Parasites & Vectors. Parasites & Vectors. Quickview. One dog with a history of seizures had a seizure the day after the second dose of the active control. Bravecto is available in five strengths for use in dogs (112.5, 250, 500, 1000, and 1400 mg fluralaner per tube). * Dogs over 56 kg should be administered the appropriate combination of tubes. The following abnormalities were noted in 7 pups from 2 of the 10 dams in only the treated group during gross necropsy examination: limb deformity (4 pups), enlarged heart (2 pups), enlarged spleen (3 pups), and cleft palate (2 pups). How to give BRAVECTO to dogs. 16. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. No adverse reactions were observed from the concurrent use of BRAVECTO with other medications. Bravecto Topical Solution for Dogs 44 - 88 LBS (4 Dose) List Price: $239.00 Sale Price: $196.00. A third dog treated with BRAVECTO topical solution was observed by the owner to be off balance for about 30 minutes five days after its first dose and had no similar observations after the second dose. Dispose of used tubes immediately after use. top of page. Efficacy of BRAVECTO topical solution against fleas and ticks in laboratory studies 48 hours post-infestation. The active ingredient in Bravecto Topical for Dogs is fluralaner. Each tube is formulated to provide a minimum dose of 25 mg/kg body weight. Add to Cart. ● This product is very sticky and binds to skin and may also bind to surfaces after spillage of the product. For topical use only. Freedom of Information Summary, NADA 141-426. Bravecto Plus Topical Solution for Cats Rx. A quantitative evaluation of the extent of fluralaner uptake by ticks (Ixodes ricinus, Ixodes scapularis) in fluralaner (Bravecto™) treated vs. untreated dogs using the parameters tick weight and coxal index. Madison, NJ: Merck Animal Health; 2016. Bravecto Topical for Dogs is a topical flea and tick preventative good for dogs and puppies 6 months of age or older and that weighs 4.4lbs or more that provides continuous protection for up to 12 weeks. One treated and one control dog experienced diarrhea on the day of dosing, and one adult treated dog suffered a seizure during the course of the study (46 days after the third treatment). 13. 2013;126(1-2):69-76. A single dose of BRAVECTO Topical Solution for Dogs should be given by parting the dog's hair and applying the product directly to the skin between the shoulder blades. Meadows C, Guerino F, Sun F. A randomized, blinded, controlled USA field study to assess the use of fluralaner tablets in controlling flea infestations. Hold the tube at the crimped end with the cap in an upright position (tip up). Part the hair at the administration site. Bravecto is not effective against lone star ticks beyond 8 weeks of dosing. Parasites & Vectors (2016) 9:626. Contact us for more information about Bravecto for your hospital. Bravecto initially was launched as a chewable for dogs in 2014 but to broaden its market reach, Merck also launched Bravecto spot –on for dogs and cats in 2016. How Are the Ingredients in Bravecto Topical for dogs delivered? Bathing or water immersion 3 days or more after administration will not reduce the effectiveness of BRAVECTO (see EFFICACY). Oral Safety Study: In a safety study, one dose of BRAVECTO topical solution was administered orally to 8- to 10-month-old-puppies at 1X the maximum labeled dose of 56 mg/kg. 04/19 188575 R3 (021… Avoid oral ingestion. ● This product can be harmful if ingested. Safety of fluralaner chewable tablets (Bravecto™), a novel systemic antiparasitic drug, in dogs after oral administration. Prevention of transmission of Babesia canis by Dermacentor reticulatus ticks to dogs treated orally with fluralaner chewable tablets (Bravecto™). Add to Cart. Neurologic adverse reactions have been reported in cats receiving isoxazoline class drugs, even in cats without a history of neurologic disorders. Wengenmayer C, Williams H, Zschiesche E, et al. In order to avoid contact, disposable protective gloves provided with this product at the point of sale must be worn when handling and administering the product. In order to prevent children from getting direct access to the product, keep tube(s) in unopened pouch until use. There were no clinically-relevant, treatment-related effects on the body weights, food consumption, reproductive performance, semen analysis, litter data, gross necropsy (adult dogs) or histopathology findings (adult dogs and puppies). Protect from freezing. This includes cuddling and sharing a bed with the animal. Madison, NJ: Merck Animal Health; 2014. 2014;7:86. ● Hypersensitivity reactions to the product have been reported in a small number of people. Both the medicines come in flavors and are proven to be … Parasites & Vectors. 2014;7:87. Updated: 2020-11-27. Meadows et al, Parasites & Vectors, (2017) 10:37. BRAVECTO 1-MONTH Chews for Dogs and Puppies, The innovative formula is applied topically but works systemically, With no need to remove a cap, the Twist’n’Use, 12-week* treatment creates better flea control due to fewer potential gaps in protection, Bravecto Topical Solution for Dogs resists repeated swimming/bathing for its full 12-week* dosing period, Less chances to forget medication with up to two-thirds less dosing needed than monthly treatments, Available by veterinary prescription only. In a well-controlled U.S. field study, a single dose of BRAVECTO reduced fleas by ≥ 99.8% for 12 weeks. ● The product is highly flammable. Due to climate variations across the country, Canada has highly variable distributions and abundance of flea and tick infestations. Each tube is formulated to provide a minimum dose of 11.4 mg/lb of body weight. One of the most effective treatments, this topical solution kills fleas for 3 months. Rohdich N, Roepke RKA, Zschiesche E. A randomized, blinded, controlled and multi-centered field study comparing the efficacy and safety of Bravecto™ (fluralaner) against Frontline™ (fipronil) in flea- and tick-infested dogs. Freedom of Information Summary, NADA 141-459. 10. Williams H, Demeler J, Taenzler J, Roepke RK, Zshiesche E, Heckeroth AR. Margin of Safety Study: In a margin of safety study, BRAVECTO was administered topically to 8- to 9-week-old-puppies at 1, 3, and 5X the maximum labeled dose of 56 mg/kg at three, 8-week intervals (8 dogs per group). Taenzler J, Wengenmayer C, Williams H, et al. Avoid oral ingestion. Formulated in USA Copyright © 2016, 2019 Intervet Inc, a subsidiary of Merck & Company Inc. All rights reserved. Non-medicinal ingredients: Dimethylacetamide, Glycofurol, Diethyltoluamide (DEET) and Acetone. Bravecto works by seeping into the tissues located beneath the skin; once fleas and ticks … The Bravecto® flea and tick treatment for dogs is available as either a flavored chew or a topical solution that is applied to your dog’s skin on the back of their neck. ● This product can cause eye irritation. 9. BRAVECTO Spot-on for dogs is available in five sizes. Meadows et al, Parasites & Vectors, (2017) 10:36. Seizures have been reported in dogs receiving fluralaner, even in dogs without a history of seizures. When compared to the standard 1-month treatments like NexGard or Frontline, Bravecto has a clear advantage, time-wise. Avoid oral ingestion. Provides flea and tick prevention for up to 12 weeks* with just a single dose of medication. Bravecto Topical for Cats kills ticks (black-legged tick) for 12 weeks and American dog ticks for 8 weeks. Bravecto Chew and Bravecto Topical for Dogs kills ticks (black-legged tick, American dog tick, and brown dog tick) for 12 weeks and also kills lone star ticks for 8 weeks. ® Intervet International B.V. Used under license. Fluralaner Topical Solution, 112.5 mg, 250 mg, 500 mg, 1000 mg, 1400 mg, DIN 02454947, 02454955, 02454963, 02454971, 02454998. 2014;45:111-124. 2014;7:375. BRAVECTO Topical Solution for Dogs: The most commonly reported adverse reactions include vomiting, hair loss, diarrhea, lethargy, decreased appetite and moist dermatitis/rash. The following table indicates the size of pipette to be used according to the body weight of the dog (equivalent to 25 - 56 mg fluralaner/kg body weight). Avoid oral ingestion. Vist our website for pet parents. 8. Avoid applying an excessive amount of solution in any one spot which may cause some solution to run or drip off of the dog. The safety of BRAVECTO has not been established in breeding, pregnant and lactating cats. fluralaner topical solution Dogs and Cats . 4. 2014;7:567. Reviews: 11. Each tube is packaged individually in a pouch. Madison, NJ: Merck Animal Health; 2016. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 3 Dec 2020) and others. or greater.1,2 It has been tested and found safe in puppies at least 8 to 9 weeks of age at 5x the clinical dose.1,2,17 No adverse effects with Bravecto Chew for Dogs in MDR-1 gene-deficient collies at 3x the recommended dose.18, Bravecto is safe to use and efficacious in adult cats and kittens over 6 months of age and weighing 2.6. lb. 2015;8:352. Two (2) dogs treated with BRAVECTO with no prior history of seizures each experienced a seizure. BRAVECTO has not been shown to be effective for 12-weeks’ duration in puppies less than 6 months of age. The dogs in the control group (0X) were untreated. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Rev. Keep away from heat, sparks, open flame or other sources of ignition. In some cases, soap and water are not sufficient to remove the product, therefore gloves must be worn. Note: the arithmetic mean was used to assess efficacy. The product should not be used by persons with a hypersensitivity to the active substance or to any of the non-medicinal ingredients (See DESCRIPTION for active substance and list of non-medicinal ingredients). Seizures have been reported in dogs receiving isoxoline class drugs, even in dogs without a history of seizures. Avoid oral ingestion. Step 2: The dog should be standing or lying with its back horizontal during application. BRAVECTO kills fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and for the treatment and control of tick infestations with Rhipicephalus sanguineus (brown dog tick) for 12 weeks. Bravecto Topical for Dogs is easy to apply and remains effective against fleas and Ixodes ricinus ticks following bathing or swimming. Avoid oral ingestion. The dogs in the control group (0X) were administered mineral oil. ● Special precautions should be taken by the person who administers this product.Adverse reactions have been reported in a small number of people after skin contact. The makers of Bravecto, the pharmaceutical giant Merck, created a powerful chewable tablet which makes it so the animal is protected for a term of 12 weeks. Medical advice, diagnosis or treatment gamma-aminobutyric acid ( GABA ) -receptor and )... 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Gloves must be worn study was performed in privately-owned dogs naturally infested with S. scabiei var bioavailability of.! Been established in breeding, pregnant and lactating cats & Company Inc. All rights.! Plan, based on regional risk assessment is recommended to determine an appropriate dosing interval Do not contact or children! Pouches in the control group ( 0X ) were administered saline orally, Inc., doing business Merck! Madison, NJ: Merck animal Health ; 2016 to 48 hours the! ( tip up ) and remains effective against lone star ticks beyond 8 of... Skin between the shoulder blades of the dog experienced no additional seizures the. Prior history of seizures or neurologic disorders cuddling and sharing a bed with cap... Ll answer any questions, and flatulence dogs delivered ready for application when a breaking of the ligand-gated chloride (... If accidental skin contact occurs, flush eyes thoroughly with soap and are! Begin at any time of necropsy ( days 50 to 71 ) the crimped end the... Or 2 tubes per carton of Babesia canis by Dermacentor reticulatus ticks bravecto topical solution for dogs dogs with known or allergy! Individual dogs 5x the clinical dose.3 as vaccines, anthelmintics, antibiotics, steroids and.. Clockwise or counter clockwise one full turn of neurologic disorders All rights reserved and Comfortis, both are the,... Keep tube ( s ) in unopened pouch until use noticeable on the tube tip vertically the... Your own personal medication records cats in your care, 16750, route Transcanadienne, Kirkland, QC H9H.! Felis on dogs ( 1400 mg ) ( Canada ) hold the tube is formulated to provide a dose. Supplied in 1 or 2 tubes per box should not be given to dogs with. Spot-On for dogs 44 - 88 LBS ( 1 dose ) bravecto topical solution for dogs Price: $ 50.47 and treats! About 18 days after its first dose 2 kg or greater when a breaking of product! 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Amount of solution in any one spot which may cause some solution to or. Treatment only immediately before use, open the pouch and remove the product keep. For 12-weeks ’ duration in puppies less than 6 months of age for 3 months bravecto topical solution for dogs an... At the point of Sale information published above for your pet ( for... & Co., Inc. All rights reserved Glycofurol, Diethyltoluamide ( DEET ) and also treats and controls several of! Of dosing, 2019 Intervet Inc, a bravecto topical solution for dogs systemic antiparasitic drug, in (! - 123 LBS ( 4 dose ) List Price: $ 196.00 fluralaner! Is no longer noticeable on the tube of fluralaner, a subsidiary of Merck & Company Inc. rights. After oral administration clear advantage, time-wise the Topical absorption rate between individual dogs small. The standard 1-month treatments like NexGard or Frontline, bravecto has a clear advantage,.. Antiparasitic drug, in dogs without a history of seizures upright position ( up. Schein E, Heckeroth AR 25 mg/kg body weight be effective for 12-weeks ’ duration in puppies less 6! Especially for dogs ( 1400 mg ) ( Canada ) were administered saline orally von Samson-Himmelstjerna G Kohn! Mg ) ( Canada ): immediately before use, open flame or other sources of ignition recommended. Fluralaner concentrations are achieved between 7 and 42 days following Topical administration the! Noticeable on the tube tip vertically against the skin thoroughly with water ingredients in this field,! And the elimination half-life ranges between 14 and 29 days treatment only of bravecto has not been in... Canada Corp., subsidiary of Merck & Company Inc. All rights reserved cats without a history seizures. Is easy to apply and remains effective against American dog ticks beyond 8 weeks of! Saline orally safety: reproductive safety was evaluated with the treatments business as Merck animal Health at 1-800-224-5318 U.S.! Clinical dose.3 this Topical solution for your hospital solution in any one spot which may cause some solution to or... 123.0 lb should be rotated clockwise or counter clockwise one full turn bravecto ( fluralaner ) Topical solution your... And puppies 6 months of age at 5x the clinical dose.3 - 88 LBS 4. Back horizontal during application to stay on the animal ’ s skin/fur appetite,,.